Peculiarities of Cyto- and Chemoarchitectonics of Human Entorhinal Cortex during the Fetal Period
- Authors: Zykin P.A.1, Moiseenko I.A.1, Tkachenko L.A.1, Nasyrov R.A.2, Tsvetkov E.A.1, Krasnoshchekova E.I.1
-
Affiliations:
- St. Petersburg State University
- St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 164, No 4 (2018)
- Pages: 497-501
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239711
- DOI: https://doi.org/10.1007/s10517-018-4020-2
- ID: 239711
Cite item
Abstract
We studied peculiarities of the structure of human entorhinal cortex at weeks 20-26 of gestation (10 hemispheres). The samples were Nissl-stained and immunohistochemically treated with antibodies to parvalbumin, calretinin, calbindin, and cytoskeleton proteins (MAP2 and N200). 3D-reconstruction of the entorhinal cortex from serial sections was performed, caudomedial and rostrolateral areas were isolated. Parvalbumin+ cells in layer I, discrete distribution of layer II cells with colocalization of MAP2 and calretinin at the border with layer I, and two sublayers Va and Vb with MAP2+ neurons were typical for the caudomedial area. Rostrolateral area was characterized by the homogenous layer II with big amount of cells, high density of MAP2+ neurons only in layer III, and the unique layer V. Reelin+ Cajal—Retzius cells and N200+ fiber plexus in layer I were observed in the caudomedial and rostrolateral areas of the entorhial cortex. Layer IV was represented by a cell-free desiccant.
About the authors
P. A. Zykin
St. Petersburg State University
Author for correspondence.
Email: pavel_zykin@spbu.ru
Russian Federation, St. Petersburg
I. A. Moiseenko
St. Petersburg State University
Email: pavel_zykin@spbu.ru
Russian Federation, St. Petersburg
L. A. Tkachenko
St. Petersburg State University
Email: pavel_zykin@spbu.ru
Russian Federation, St. Petersburg
R. A. Nasyrov
St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation
Email: pavel_zykin@spbu.ru
Russian Federation, St. Petersburg
E. A. Tsvetkov
St. Petersburg State University
Email: pavel_zykin@spbu.ru
Russian Federation, St. Petersburg
E. I. Krasnoshchekova
St. Petersburg State University
Email: pavel_zykin@spbu.ru
Russian Federation, St. Petersburg