Expression of Adhesion Molecules in Activated Endothelium after Interaction with Mesenchymal Stromal Cells
- Authors: Zhidkova O.V.1, Andreeva E.R.1, Buravkova L.B.1
-
Affiliations:
- Institute of Medicobiological Problems, Russian Academy of Sciences
- Issue: Vol 164, No 4 (2018)
- Pages: 453-455
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239679
- DOI: https://doi.org/10.1007/s10517-018-4010-4
- ID: 239679
Cite item
Abstract
The studied the expression of intercellular adhesion molecules and transcription of the corresponding genes in intact and activated endothelial cells both in monoculture and during interaction with mesenchymal stromal cells. It was found that the levels of integrin-α1 and VE-cadherin mRNA increased during co-culturing. TNFα-induced activation of endothelial cells enhanced expression of integrin-α1 both at the mRNA and protein synthesis stages and had no effect on the level of VE-cadherin. Direct contact with mesenchymal stromal cells did not eliminate the effect of endothelial cell activation, but expression of integrin-α1 and VE-cadherin in activated endothelial cells tended to decrease.
About the authors
O. V. Zhidkova
Institute of Medicobiological Problems, Russian Academy of Sciences
Email: buravkova@imbp.ru
Russian Federation, Moscow
E. R. Andreeva
Institute of Medicobiological Problems, Russian Academy of Sciences
Email: buravkova@imbp.ru
Russian Federation, Moscow
L. B. Buravkova
Institute of Medicobiological Problems, Russian Academy of Sciences
Author for correspondence.
Email: buravkova@imbp.ru
Russian Federation, Moscow