Immunomorphological Changes in the Olfactory Bulbs of Rats after Intranasal Administration of Rotenone
- Authors: Voronkov D.N.1, Kutukova K.A.1, Ivanov M.V.1, Khudoerkov R.M.1
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Affiliations:
- Research Center of Neurology
- Issue: Vol 164, No 2 (2017)
- Pages: 203-206
- Section: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/239490
- DOI: https://doi.org/10.1007/s10517-017-3958-9
- ID: 239490
Cite item
Abstract
Changes in the structure of the olfactory bulbs after long-term intranasal administration of pesticide rotenone, a classical inductor of parkinsonism, to rats were studied by the methods of immunomorphology. In rats intranasally receiving rotenone in a dose of 2.5 mg/kg every other day over 2 weeks, a decrease in the density of dopaminergic neurons and the area of astrocyte processes in the olfactory bulbs, activation of microglia in the glomerular layer, and enhanced α-synuclein phosphorylation and its accumulation in the bodies of mitral layer neurons were observed. The observed changes agree with the hypothesis on pathological α-synuclein transport via the olfactory route in Parkinson’s disease and confirm relevance of the rotenone model of Parkinson’s disease for studies of the pathological accumulation of α-synuclein.
About the authors
D. N. Voronkov
Research Center of Neurology
Author for correspondence.
Email: neurolab@yandex.ru
Russian Federation, Moscow
K. A. Kutukova
Research Center of Neurology
Email: neurolab@yandex.ru
Russian Federation, Moscow
M. V. Ivanov
Research Center of Neurology
Email: neurolab@yandex.ru
Russian Federation, Moscow
R. M. Khudoerkov
Research Center of Neurology
Email: neurolab@yandex.ru
Russian Federation, Moscow