Gene TNF Polymorphism -308G>A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis
- Authors: Topchieva L.V.1, Dudanova O.P.2, Kurbatova I.V.1
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Affiliations:
- Institute of Biology, Karelian Research Center, Russian Academy of Sciences
- Petrozavodsk State University
- Issue: Vol 164, No 2 (2017)
- Pages: 181-185
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/239465
- DOI: https://doi.org/10.1007/s10517-017-3953-1
- ID: 239465
Cite item
Abstract
Association of TNF gene polymorphism -308G>A with the development of nonalcoholic steatohepatitis in the Russian population was revealed. Carriers of allele A of the TNF gene marker -308G>A have significantly higher risk of nonalcoholic steatohepatitis development: OR=1.69 (1.05; 2.71). Allele A carriage by this marker predicts an increase in the basal HDL level and a decrease in LDL and IL-10 levels in the blood of healthy subjects. Patients with nonalcoholic steatohepatitis, differing by the TNF gene -308G>A marker genotype, differ by the time course of the markers of hepatocellular damage (ALT, AST), activity of hepatocyte apoptosis (tissue polypeptide-specific antigen), and activation of specific humoral immunity (γ-globulin) in response to therapy with ursodeoxycholic acid in a dose of 10-15 mg/kg over 4-6 weeks. Carriers of allele A of the TNF gene polymorphic marker -308G>A are more sensitive to ursodeoxycholic acid therapy than carriers of GG genotype.
About the authors
L. V. Topchieva
Institute of Biology, Karelian Research Center, Russian Academy of Sciences
Email: irina7m@yandex.ru
Russian Federation, Moscow
O. P. Dudanova
Petrozavodsk State University
Email: irina7m@yandex.ru
Russian Federation, Petrozavodsk, Republic of Karelia
I. V. Kurbatova
Institute of Biology, Karelian Research Center, Russian Academy of Sciences
Author for correspondence.
Email: irina7m@yandex.ru
Russian Federation, Moscow