Comparison of the Pharmacological Effects of Dimeric Dipeptide Nerve Growth Factor Mimetic GK-2 and Mexidol on the Model of Ischemic Stroke in Rats
- Authors: Povarnina P.Y.1, Volkova A.A.1, Gudasheva T.A.1, Seredenin S.B.2
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Affiliations:
- Laboratory of Peptide Bioregulation, V. V. Zakusov Research Institute of Pharmacology
- Department of Pharmacogenetics, V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 164, No 2 (2017)
- Pages: 173-176
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239455
- DOI: https://doi.org/10.1007/s10517-017-3951-3
- ID: 239455
Cite item
Abstract
We compared the effects of GK-2 (dimeric dipeptide mimetic of nerve growth factor) and Mexidol (standard preparation for the therapy of stroke) on rat model of transient occlusion of the middle cerebral artery. GK-2 and Mexidol were administered intraperitoneally in the most active doses (1 and 100 mg/kg, respectively) 6 h after surgery and then once a day for 6 days. The preparations reduced the volume of cerebral infarction (by 60 and 30%, respectively). At the same time, GK-2 had a pronounced and statistically more reliable effect in a dose that is lower by two orders of magnitude. In addition, GK-2 significantly reduced the neurological deficit in the limb placement test, while Mexidol was ineffective in this test.
About the authors
P. Yu. Povarnina
Laboratory of Peptide Bioregulation, V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: povarnina@gmail.com
Russian Federation, Moscow
A. A. Volkova
Laboratory of Peptide Bioregulation, V. V. Zakusov Research Institute of Pharmacology
Email: povarnina@gmail.com
Russian Federation, Moscow
T. A. Gudasheva
Laboratory of Peptide Bioregulation, V. V. Zakusov Research Institute of Pharmacology
Email: povarnina@gmail.com
Russian Federation, Moscow
S. B. Seredenin
Department of Pharmacogenetics, V. V. Zakusov Research Institute of Pharmacology
Email: povarnina@gmail.com
Russian Federation, Moscow