Involvement of Microflora Metabolites in Up-Regulation of Electrical Activity in Rat Small Intestine
- Authors: Tropskaya N.S.1, Kislyakova E.A.1, Popova T.S.1
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Affiliations:
- N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health
- Issue: Vol 163, No 6 (2017)
- Pages: 796-800
- Section: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/239276
- DOI: https://doi.org/10.1007/s10517-017-3906-8
- ID: 239276
Cite item
Abstract
The study examined implication of tributyrin, a metabolic precursor in small intestinal microflora, in stimulation of electrical activity of duodenum and jejunum. Enteral administration of tributyrin enhanced electrical activity of both examined structures in small intestine with elimination of the rest periods. The stimulatory effect was manifested in a prolongation of the periods of irregular activity. The up-regulating effects of tributyrin on electrical activity in upper segments of small intestine are mediated via the cholecystokinin receptors being also associated with activation of cholinergic and blockade of nitrinergic signal transduction pathways.
About the authors
N. S. Tropskaya
N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health
Author for correspondence.
Email: ntropskaya@mail.ru
Russian Federation, Moscow
E. A. Kislyakova
N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health
Email: ntropskaya@mail.ru
Russian Federation, Moscow
T. S. Popova
N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health
Email: ntropskaya@mail.ru
Russian Federation, Moscow