Regenerative Potential of Spermatogonial Stem Cells, Endothelial Progenitor Cells, and Epithelial Progenitor Cells of C57Bl/6 Male Mice with Metabolic Disorders
- Authors: Skurikhin E.G.1, Pakhomova A.V.1, Pershina O.V.1, Ermolaeva L.A.1, Krupin V.A.1, Ermakova N.N.1, Pan E.S.1, Kudryashova A.I.1, Rybalkina O.Y.1, Pavlovskaya T.B.1, Litvyakov N.V.2, Goldberg V.E.2, Dygai A.M.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Tomsk National Research Medical Center, Russian Academy of Sciences
- Issue: Vol 163, No 2 (2017)
- Pages: 239-244
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238785
- DOI: https://doi.org/10.1007/s10517-017-3775-1
- ID: 238785
Cite item
Abstract
The properties of spermatogonial stem cells, endothelial progenitor cells, and the epithelial progenitors of C57Bl/6 mice under conditions of metabolic disorders were studied using the model of busulfan-induced suppression of spermatogenesis and in vitro culture technique. Spermatogonial stem cells CD117—CD90+ and epithelial progenitors CD45—CD31—Sca-1+CD49f+ derived from the testes of mice with metabolic disturbances demonstrated 17- and 28-fold increase in the respective cell mass and generated cell colonies in vitro. In contrast, spermatogonial stem cells with immune phenotype CD51—CD24+CD52+ had reduced selfrenewal capacity. Spermatogonial stem cells CD117—CD90+ and CD117+CD90+ as well as endothelial progenitors CD45—CD31+ derived from the testes of donor mice with metabolic disorders demonstrated high transplantation capacity in C57Bl/6 mouse testes damaged by cytostatic busulfan.
About the authors
E. G. Skurikhin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
A. V. Pakhomova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Author for correspondence.
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
O. V. Pershina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
L. A. Ermolaeva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
V. A. Krupin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
N. N. Ermakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
E. S. Pan
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
A. I. Kudryashova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
O. Yu. Rybalkina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
T. B. Pavlovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
N. V. Litvyakov
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
V. E. Goldberg
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: angelinapakhomova2011@gmail.com
Russian Federation, Tomsk