Features of Blood Supply to Axillary Lymph Nodes in Breast Cancer Patients
- Authors: Maiborodin I.V.1, Kozyakov A.E.2, Babayants E.V.2, Krasil’nikov S.E.1
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Affiliations:
- Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Novosibirsk Regional Clinical Oncological Clinics
- Issue: Vol 163, No 1 (2017)
- Pages: 82-86
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238660
- DOI: https://doi.org/10.1007/s10517-017-3743-9
- ID: 238660
Cite item
Abstract
Numerical density of vessels in axillary lymph node structures in breast cancer patients was studied by light microscopy with antibodies to CD34. The correlation between the stage of breast cancer and vascularization of lymph nodes was analyzed. The development of breast cancer was followed by rapid and significant increase in the number of blood vessel in axillary lymph nodes in general and in all their specific areas, especially in the paracortex and medullary substance. Strong or very strong positive correlation between the stage of tumor process and parameters of vascularization was observed in various areas of the axillary lymph nodes. No significant differences in node vascularization were observed between women without breast cancer and women with stage I breast cancer; the differences were found only starting from stage II. Considerable vascularization of lymph nodes can be a symptom of malignant tumor growth in the area of lymph collection. The duration of the tumor process and the size of the tumor can be indirectly evaluated by the increase in vessel number in lymph nodes.
About the authors
I. V. Maiborodin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: imai@mail.ru
Russian Federation, Novosibirsk
A. E. Kozyakov
Novosibirsk Regional Clinical Oncological Clinics
Email: imai@mail.ru
Russian Federation, Novosibirsk
E. V. Babayants
Novosibirsk Regional Clinical Oncological Clinics
Email: imai@mail.ru
Russian Federation, Novosibirsk
S. E. Krasil’nikov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk