Comparative Analysis of Structural Responses of Rat Subcutaneous Fat on the Implantation of Samples of Polymethyl Methacrylate with Hydrophobic and Hydrophilic Surface
- Authors: Kudasova E.O.1, Vlasova L.F.2, Semenov D.E.2, Lushnikova E.L.2
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Affiliations:
- I. M. Sechenov First Moscow State Medical University, the Ministry of Health of the Russian Federation
- Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 162, No 5 (2017)
- Pages: 687-689
- Section: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/238470
- DOI: https://doi.org/10.1007/s10517-017-3688-z
- ID: 238470
Cite item
Abstract
Morphological analysis of the subcutaneous fat was performed in rats after subcutaneous implantation of basic dental plastic materials with different hydrophobic and hydrophilic properties. It was shown that subcutaneous implantation of dental plastics with mostly hydrophobic surface and low biocompatibility induced destructive and inflammatory processes of various intensities, sometimes with allergic component; morphological signs of processes persisted for 6 weeks. Modification of basic plastics using glow-discharge plasma and enhancement of their hydrophilicity and biocompatibility significantly reduced the intensity of destructive and inflammatory processes and ensured more rapid (in 2 weeks) repair of the destroyed tissues with the formation of fibrous capsule around the implant.
About the authors
E. O. Kudasova
I. M. Sechenov First Moscow State Medical University, the Ministry of Health of the Russian Federation
Email: pathol@inbox.ru
Russian Federation, Moscow
L. F. Vlasova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
D. E. Semenov
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
E. L. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk