Possible Role of Polymorphisms in TNFA, NFKB1, and CASP8 Gene Promoter Areas in the Development of Chronic Lymphocytic Leukemia
- Authors: Ovsepyan V.A.1, Shubenkina A.A.1, Zotova E.N.1
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Affiliations:
- Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
- Issue: Vol 162, No 5 (2017)
- Pages: 650-653
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/238432
- DOI: https://doi.org/10.1007/s10517-017-3679-0
- ID: 238432
Cite item
Abstract
We studied the relationship between polymorphisms rs1800629 (-308G>A), rs28362491 (-94ins>del), and rs3834129 (-652ins>del) in the promoter regions of TNFA, NFKB1, and CASP8 genes, respectively, encoding TNF-α, nuclear transcription factor κB1 (NF-κB1), and caspase 8 (CASP8), and the risk and stages of chronic lymphocytic leukemia in ethnic Russians, residents of the Vyatka region of Russia. Allele -308A, genotype -308AA, and -308A genotypes (-308AA/-308AG) were associated with the risk of this pathology (OR=1.64, 95%CI 1.14-2.37, p=0.007; OR=4.48, 95%CI 1.20-16.80, p=0.02, and OR=1.57, 95%CI 1.05-2.36, p=0.03). In addition, NFKB1 allele -94del and genotype -94del/del were associated with advanced stages of the disease at the time of diagnosis (OR=0.66, 95%CI 0.46-0.97, p=0.03 and OR=0.43, 95%CI 0.20-0.92, p=0.03). These data suggest that -308G>A and -94ins>del polymorphisms of genes TNFA and NFKB1, respectively, can be involved in the pathogenesis of chronic lymphocytic leukemia.
About the authors
V. A. Ovsepyan
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: vovsepyan@mail.ru
Russian Federation, Kirov
A. A. Shubenkina
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
Email: vovsepyan@mail.ru
Russian Federation, Kirov
E. N. Zotova
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
Email: vovsepyan@mail.ru
Russian Federation, Kirov