Study of SMAD-Dependent Signal Pathway in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H1N1 Virus
- Authors: Shatskaya E.V.1, Kovner A.V.1, Potapova O.V.1, Cherdantseva L.A.1, Shkurupy V.A.1, Shestopalov A.M.1
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Affiliations:
- Research Institute of Experimental and Clinical Medicine
- Issue: Vol 162, No 5 (2017)
- Pages: 647-649
- Section: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/238431
- DOI: https://doi.org/10.1007/s10517-017-3678-1
- ID: 238431
Cite item
Abstract
Early fibrosis of the visceral organs is one of the main complications of infection caused by influenza A virus. Structural manifestations and molecular regulators of the epithelialmesenchymal transformation as a possible mechanism of fibrosis progression were studied in mice infected with influenza A/H1N1 A/Tomsk/13/2010 virus. We found early fibrosis of the lungs against the background of minor changes in fibroblast count. However, enhanced expression of TGF-β and SMAD-2 by macrophages and alveolocytes attested to possible development of epithelial-mesenchymal transformation and its contribution to activation of fibrogenesis process in the lungs.
About the authors
E. V. Shatskaya
Research Institute of Experimental and Clinical Medicine
Author for correspondence.
Email: shatskaya110@gmail.com
Russian Federation, Novosibirsk
A. V. Kovner
Research Institute of Experimental and Clinical Medicine
Email: shatskaya110@gmail.com
Russian Federation, Novosibirsk
O. V. Potapova
Research Institute of Experimental and Clinical Medicine
Email: shatskaya110@gmail.com
Russian Federation, Novosibirsk
L. A. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Email: shatskaya110@gmail.com
Russian Federation, Novosibirsk
V. A. Shkurupy
Research Institute of Experimental and Clinical Medicine
Email: shatskaya110@gmail.com
Russian Federation, Novosibirsk
A. M. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: shatskaya110@gmail.com
Russian Federation, Novosibirsk