Study of SMAD-Dependent Signal Pathway in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H1N1 Virus


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Аннотация

Early fibrosis of the visceral organs is one of the main complications of infection caused by influenza A virus. Structural manifestations and molecular regulators of the epithelialmesenchymal transformation as a possible mechanism of fibrosis progression were studied in mice infected with influenza A/H1N1 A/Tomsk/13/2010 virus. We found early fibrosis of the lungs against the background of minor changes in fibroblast count. However, enhanced expression of TGF-β and SMAD-2 by macrophages and alveolocytes attested to possible development of epithelial-mesenchymal transformation and its contribution to activation of fibrogenesis process in the lungs.

Авторлар туралы

E. Shatskaya

Research Institute of Experimental and Clinical Medicine

Хат алмасуға жауапты Автор.
Email: shatskaya110@gmail.com
Ресей, Novosibirsk

A. Kovner

Research Institute of Experimental and Clinical Medicine

Email: shatskaya110@gmail.com
Ресей, Novosibirsk

O. Potapova

Research Institute of Experimental and Clinical Medicine

Email: shatskaya110@gmail.com
Ресей, Novosibirsk

L. Cherdantseva

Research Institute of Experimental and Clinical Medicine

Email: shatskaya110@gmail.com
Ресей, Novosibirsk

V. Shkurupy

Research Institute of Experimental and Clinical Medicine

Email: shatskaya110@gmail.com
Ресей, Novosibirsk

A. Shestopalov

Research Institute of Experimental and Clinical Medicine

Email: shatskaya110@gmail.com
Ресей, Novosibirsk

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