Pharmacological Analysis of the Therapeutic Effect of Radioprotectors Cystamine and Indralin in the Capacity of Radiomitigators
- Authors: Vasin M.V.1, Ushakov I.B.1, Kovtun V.Y.2, Komarova S.N.1, Semenova L.A.1, Galkin A.A.1, Afanas’ev R.V.1, Bukhtiyarov I.V.1
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Affiliations:
- Research Institute of Occupational Medicine, Russian Academy of Sciences
- Research and Development Center “Farmzaschita”, the Federal Medical-Biological Agency of Russia
- Issue: Vol 162, No 4 (2017)
- Pages: 466-469
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238304
- DOI: https://doi.org/10.1007/s10517-017-3641-1
- ID: 238304
Cite item
Abstract
The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body 60Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation. Moreover, summation of the radioprotective and therapeutic effects of the radioprotector was revealed under these conditions. In mice and rats, α1-adrenoreceptor blocker terazosin did not abolish the therapeutic effect of indralin administrated after irradiation, but blocked the radioprotective effect of indralin applied prior to irradiation. At the same time, 5-HT2 serotonin receptor blocker tropoxin abolished the therapeutic effect of indralin without affecting its radioprotective activity.
About the authors
M. V. Vasin
Research Institute of Occupational Medicine, Russian Academy of Sciences
Author for correspondence.
Email: mikhail-vvasin@yandex.ru
Russian Federation, Moscow
I. B. Ushakov
Research Institute of Occupational Medicine, Russian Academy of Sciences
Email: mikhail-vvasin@yandex.ru
Russian Federation, Moscow
V. Yu. Kovtun
Research and Development Center “Farmzaschita”, the Federal Medical-Biological Agency of Russia
Email: mikhail-vvasin@yandex.ru
Russian Federation, Khimki, Moscow Region
S. N. Komarova
Research Institute of Occupational Medicine, Russian Academy of Sciences
Email: mikhail-vvasin@yandex.ru
Russian Federation, Moscow
L. A. Semenova
Research Institute of Occupational Medicine, Russian Academy of Sciences
Email: mikhail-vvasin@yandex.ru
Russian Federation, Moscow
A. A. Galkin
Research Institute of Occupational Medicine, Russian Academy of Sciences
Email: mikhail-vvasin@yandex.ru
Russian Federation, Moscow
R. V. Afanas’ev
Research Institute of Occupational Medicine, Russian Academy of Sciences
Email: mikhail-vvasin@yandex.ru
Russian Federation, Moscow
I. V. Bukhtiyarov
Research Institute of Occupational Medicine, Russian Academy of Sciences
Email: mikhail-vvasin@yandex.ru
Russian Federation, Moscow