Effect of Mifepristone on Corticosteroid Production in Vitro by Adrenal Glands of Rats with Streptozotocin Diabetes
- Authors: Kuznetsova N.V.1, Palchikova N.A.1, Selyatitskaya V.G.1, Kuzminova O.I.1
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Affiliations:
- Research Institute of Experimental and Clinical Medicine
- Issue: Vol 162, No 3 (2017)
- Pages: 327-330
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238172
- DOI: https://doi.org/10.1007/s10517-017-3607-3
- ID: 238172
Cite item
Abstract
Changes in pregnenolone and corticosterone production by the adrenal glands of normoglycemic rats receiving the course of intraperitoneal mifepristone or NaCl administration were co-directed, but differed in magnitude. In rats with hyperglycemia, corticosteroid production increased after NaCl administration over 5 days and returned to the initial values after 15-day administration. On the contrary, pregnenolone and corticosterone production was suppressed after 5-day course of mifepristone, but significantly increased after mifepristone administration for 15 days. Intraperitoneal mifepristone administration almost completely abolished the response of rat adrenal glands with normo- and hyperglycemia to ACTH in vitro; this effect did not depend on the duration of administration.
About the authors
N. V. Kuznetsova
Research Institute of Experimental and Clinical Medicine
Email: labend@mail.ru
Russian Federation, Novosibirsk
N. A. Palchikova
Research Institute of Experimental and Clinical Medicine
Author for correspondence.
Email: labend@mail.ru
Russian Federation, Novosibirsk
V. G. Selyatitskaya
Research Institute of Experimental and Clinical Medicine
Email: labend@mail.ru
Russian Federation, Novosibirsk
O. I. Kuzminova
Research Institute of Experimental and Clinical Medicine
Email: labend@mail.ru
Russian Federation, Novosibirsk