Morphogenesis of Experimental Infection Caused by Plasmid Variants of Yersinia pseudotuberculosis
- Authors: Somova L.M.1, Drobot E.I.1, Plekhova N.G.1,2, Lyapun I.N.1, Shubin F.N.1
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Affiliations:
- G. P. Somov Research Institute of Epidemiology and Microbiology
- Pacific State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 162, No 2 (2016)
- Pages: 264-268
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238100
- DOI: https://doi.org/10.1007/s10517-016-3591-z
- ID: 238100
Cite item
Abstract
The dynamics of pathomorphological changes in response to infection with plasmid variants of Yersinia pseudotuberculosis was studied in experimental animals. Variability of cell injuries in pseudotuberculosis histopathology depended on the plasmid-associated virulence of the infection agent. Infection with highly virulent two-plasmid strain pYV48:pVM82 MDa and Y. pseudotuberculosis strain with low virulence with the only plasmid pVM82 MDa led to the development of cell destruction (necrosis and apoptosis) in the target organs. Apoptosis predominated in response to infection by plasmid variant pVM82 MDa with low virulence.
About the authors
L. M. Somova
G. P. Somov Research Institute of Epidemiology and Microbiology
Author for correspondence.
Email: l_somova@mail.ru
Russian Federation, Vladivostok
E. I. Drobot
G. P. Somov Research Institute of Epidemiology and Microbiology
Email: l_somova@mail.ru
Russian Federation, Vladivostok
N. G. Plekhova
G. P. Somov Research Institute of Epidemiology and Microbiology; Pacific State Medical University, Ministry of Health of the Russian Federation
Email: l_somova@mail.ru
Russian Federation, Vladivostok; Vladivostok
I. N. Lyapun
G. P. Somov Research Institute of Epidemiology and Microbiology
Email: l_somova@mail.ru
Russian Federation, Vladivostok
F. N. Shubin
G. P. Somov Research Institute of Epidemiology and Microbiology
Email: l_somova@mail.ru
Russian Federation, Vladivostok