Structural and Functional Analysis of the Small Intestine in Rats After Six-Month-Long Exposure to Multiwalled Carbon Nanotubes
- Authors: Belyaeva N.N.1, Sycheva L.P.1, Savostikova O.N.1
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Affiliations:
- A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 6 (2016)
- Pages: 826-828
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237820
- DOI: https://doi.org/10.1007/s10517-016-3521-0
- ID: 237820
Cite item
Abstract
Structural and functional analysis of the small intestinal villi in outbred rats was performed after treatment with multiwalled carbon nanotube suspension in comparison with the effects of fine charcoal suspension. Chronic (6 months) exposure to nanotubes in a concentration of 0.2 mg/liter and, particularly, 0.5 mg/liter induced significant changes in the small intestine manifested in a decrease in the number of villi without changes in the brush border integrity, increase in the number of destructed villi, and appearance of villi with apical necrosis. These abnormalities were not observed after treatment for a shorter period of time (2 months).
About the authors
N. N. Belyaeva
A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Ministry of Health of the Russian Federation
Email: savon05@yandex.ru
Russian Federation, Moscow
L. P. Sycheva
A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Ministry of Health of the Russian Federation
Email: savon05@yandex.ru
Russian Federation, Moscow
O. N. Savostikova
A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Ministry of Health of the Russian Federation
Author for correspondence.
Email: savon05@yandex.ru
Russian Federation, Moscow