Expression of Molecular Markers of Angiogenesis, Lymphangiogenesis, and Proliferation Depending on the Stage of Skin Melanoma
- Authors: Bgatova N.P.1, Lomakin A.I.2, Fursov S.A.2, Kachesov I.V.2, Chepko S.A.2, Isakova N.B.2, Borodin Y.I.1, Voytsitsky V.E.2, Konenkov V.I.1
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Affiliations:
- Institute of Clinical and Experimental Lymphology
- Novosibirsk Regional Clinical Oncological Center
- Issue: Vol 161, No 4 (2016)
- Pages: 542-546
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/237579
- DOI: https://doi.org/10.1007/s10517-016-3456-5
- ID: 237579
Cite item
Abstract
The expression of molecular markers characterizing activity of the tumor process and metastases (proliferation marker Ki-67, angiogenesis marker CD34, and lymphangiogenesis markers podoplanin and LYVE-1) was assessed by immunohictochemical method in the primary tumor specimens collected during surgery for cutaneous melanoma (40 patients). Proliferative activity of the tumor tissue and volume density of peritumoral blood and lymph vessels increased with increasing tumor malignancy, which could indicate the risk of metastases.
About the authors
N. P. Bgatova
Institute of Clinical and Experimental Lymphology
Author for correspondence.
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
A. I. Lomakin
Novosibirsk Regional Clinical Oncological Center
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
S. A. Fursov
Novosibirsk Regional Clinical Oncological Center
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
I. V. Kachesov
Novosibirsk Regional Clinical Oncological Center
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
S. A. Chepko
Novosibirsk Regional Clinical Oncological Center
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
N. B. Isakova
Novosibirsk Regional Clinical Oncological Center
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
Yu. I. Borodin
Institute of Clinical and Experimental Lymphology
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
V. E. Voytsitsky
Novosibirsk Regional Clinical Oncological Center
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk
V. I. Konenkov
Institute of Clinical and Experimental Lymphology
Email: n_bgatova@ngs.ru
Russian Federation, Novosibirsk