Email this article Effect of Hepatitis C Virus Coinfection on the Content of CD4+ and CD8+ T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy
- Authors: Korolevskaya L.B.1,2, Shmagel K.V.1,2, Saidakova E.V.1,2, Shmagel N.G.1,3, Slobodchikova S.V.1,2, Chereshnev V.A.1,4,5
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Affiliations:
- Perm State National Research University
- Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- Perm Regional Center for Prevention of AIDS and Infectious Diseases
- Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
- Ural Federal University Named after the First President of Russia B. N. Yeltsin
- Issue: Vol 161, No 2 (2016)
- Pages: 281-283
- Section: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/237337
- DOI: https://doi.org/10.1007/s10517-016-3395-1
- ID: 237337
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Abstract
We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4+ T cells and an increase in the count of central CD8+ memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4+ memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.
About the authors
L. B. Korolevskaya
Perm State National Research University; Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Author for correspondence.
Email: bioqueen@mail.ru
Russian Federation, Perm; Ekaterinburg
K. V. Shmagel
Perm State National Research University; Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: bioqueen@mail.ru
Russian Federation, Perm; Ekaterinburg
E. V. Saidakova
Perm State National Research University; Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: bioqueen@mail.ru
Russian Federation, Perm; Ekaterinburg
N. G. Shmagel
Perm State National Research University; Perm Regional Center for Prevention of AIDS and Infectious Diseases
Email: bioqueen@mail.ru
Russian Federation, Perm; Perm
S. V. Slobodchikova
Perm State National Research University; Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: bioqueen@mail.ru
Russian Federation, Perm; Ekaterinburg
V. A. Chereshnev
Perm State National Research University; Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences; Ural Federal University Named after the First President of Russia B. N. Yeltsin
Email: bioqueen@mail.ru
Russian Federation, Perm; Ekaterinburg; Ekaterinburg
