Effect of Audiogenic Seizures on the Dynamics of Fatty Acid Composition of Hippocampal Dental Gyrus in Krushinsky-Molodkina Rats
- Authors: Kulagina T.P.1, Aripovsky A.V.2, Savina T.A.3, Godukhin O.V.3
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Affiliations:
- Institute of Cell Biophysics, Russian Academy of Sciences
- State Research Center of Applied Microbiology and Biotechnology
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Issue: Vol 161, No 2 (2016)
- Pages: 241-244
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/237300
- DOI: https://doi.org/10.1007/s10517-016-3386-2
- ID: 237300
Cite item
Abstract
Changes in the fatty acid composition of the hippocampal dentate gyrus in Krushinsky–Molodkina rats with hereditary predisposition to audiogenic seizures were studied in 1, 3, and 14 days after 1 or 5 seizures. Seizure activity changed the content of saturated and monounsaturated as well as polyunsaturated fatty acids at different terms after seizures. After seizures, the content of individual fatty acids changed in different directions. Similar shifts after 1 and 5 seizures were observed only for eicosapentaenoic acid at all observation terms. More pronounced changes in fatty acid composition were observed after 5 seizures. These results can be useful for the development of new approaches to correction of seizure activity.
About the authors
T. P. Kulagina
Institute of Cell Biophysics, Russian Academy of Sciences
Author for correspondence.
Email: tpkulagina@rambler.ru
Russian Federation, Pushchino
A. V. Aripovsky
State Research Center of Applied Microbiology and Biotechnology
Email: tpkulagina@rambler.ru
Russian Federation, Obolensk
T. A. Savina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: tpkulagina@rambler.ru
Russian Federation, Pushchino
O. V. Godukhin
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: tpkulagina@rambler.ru
Russian Federation, Pushchino