Atrial Natriuretic Peptide Inhibits Spontaneous Contractile Activity of Lymph Nodes
- Authors: Lobov G.I.1, Pan’kova M.N.1
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Affiliations:
- I. P. Pavlov Institute of Physiology of Russian Academy of Sciences
- Issue: Vol 161, No 2 (2016)
- Pages: 221-223
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237280
- DOI: https://doi.org/10.1007/s10517-016-3380-8
- ID: 237280
Cite item
Abstract
Atrial natriuretic peptide dose-dependently inhibited spontaneous phase and tonic activity of smooth muscle strips from the capsule of isolated bovine mesenteric lymph nodes. Pretreatment with L-NAME, diclofenac, and methylene blue had practically no effect on the peptide-induced relaxation responses. In contrast, glibenclamide significantly reduced the inhibitory effect of atrial natriuretic peptide. We suppose that the NO-dependent and cyclooxygenase signaling pathways are not involved in implementation of the inhibitory effects of atrial natriuretic peptide. ATP-sensitive K+-channels of the smooth muscle cell membrane are the last component in the signaling pathway leading to relaxation of smooth muscles of the lymph node capsule caused by atrial natriuretic peptide; activation of these channels leads to membrane hyperpolarization and smooth muscle relaxation.
About the authors
G. I. Lobov
I. P. Pavlov Institute of Physiology of Russian Academy of Sciences
Author for correspondence.
Email: gilobov@yandex.ru
Russian Federation, St. Petersburg
M. N. Pan’kova
I. P. Pavlov Institute of Physiology of Russian Academy of Sciences
Email: gilobov@yandex.ru
Russian Federation, St. Petersburg