A Model of Cadmium Uptake and Transport in Caco-2 Cells
- Authors: Gerasimenko T.N.1, Senyavina N.V.1, Anisimov N.U.2, Tonevitskaya S.A.2
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Affiliations:
- BioCilicum Research and Production Center
- Moscow State University of Mechanical Engineering (MAMI)
- Issue: Vol 161, No 1 (2016)
- Pages: 187-192
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/237258
- DOI: https://doi.org/10.1007/s10517-016-3373-7
- ID: 237258
Cite item
Abstract
We created a physiologically substantiated kinetic model of cadmium transport and toxicity in intestinal cell model (Caco-2 cells). Transcriptome profiling of Caco-2 cells revealed high content of transporter DMT1 and ZIP14 and intensive expression of some calcium channels of the CACN family. The mathematical model describing three types of transporters, as well as intracellular cadmium binding with metallothionein and excretion through the basolateral membrane allowed us to construct cadmium uptake and transport curves that approximated the previously obtained experimental data. Using the proposed model, we determined toxic intracellular cadmium concentration leading to cell death and impairing the integrity of cell monolayer and described cadmium transport in this case.
About the authors
T. N. Gerasimenko
BioCilicum Research and Production Center
Email: n.seniavina@bioclinicum.com
Russian Federation, Moscow
N. V. Senyavina
BioCilicum Research and Production Center
Author for correspondence.
Email: n.seniavina@bioclinicum.com
Russian Federation, Moscow
N. U. Anisimov
Moscow State University of Mechanical Engineering (MAMI)
Email: n.seniavina@bioclinicum.com
Russian Federation, Moscow
S. A. Tonevitskaya
Moscow State University of Mechanical Engineering (MAMI)
Email: n.seniavina@bioclinicum.com
Russian Federation, Moscow