Adenylyl Cyclase-Associated Protein 1 in the Development of Head and Neck Squamous Cell Carcinomas
- Authors: Kakurina G.V.1, Kondakova I.V.1, Cheremisina O.V.1, Shishkin D.A.1, Choinzonov E.L.1
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Affiliations:
- Tomsk Cancer Research Institute
- Issue: Vol 160, No 5 (2016)
- Pages: 695-697
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/236897
- DOI: https://doi.org/10.1007/s10517-016-3252-2
- ID: 236897
Cite item
Abstract
We compared the content of adenylyl cyclase-associated protein 1 (CAP1) in the blood and tissues of patients with head and neck squamous cell carcinomas (with and without regional metastases), patients with chronic inflammatory diseases aggravated by laryngeal and laryngopharyngeal dysplasia, and healthy individuals. The data suggest that serum CAP1 concentration correlated with the depth of primary tumor invasion and the presence of regional metastases. In cancer patients, the serum level of CAP1 was lower than in patients with laryngeal and laryngopharyngeal dysplasia, which can be of importance for differential and timely diagnostics of malignant tumors.
About the authors
G. V. Kakurina
Tomsk Cancer Research Institute
Author for correspondence.
Email: kakurinagv@oncology.tomsk.ru
Russian Federation, Tomsk
I. V. Kondakova
Tomsk Cancer Research Institute
Email: kakurinagv@oncology.tomsk.ru
Russian Federation, Tomsk
O. V. Cheremisina
Tomsk Cancer Research Institute
Email: kakurinagv@oncology.tomsk.ru
Russian Federation, Tomsk
D. A. Shishkin
Tomsk Cancer Research Institute
Email: kakurinagv@oncology.tomsk.ru
Russian Federation, Tomsk
E. L. Choinzonov
Tomsk Cancer Research Institute
Email: kakurinagv@oncology.tomsk.ru
Russian Federation, Tomsk