Role of Melatonin in the Regulation of Differentiation of T Cells Producing Interleukin-17 (Th17)
- Authors: Kuklina E.M.1, Glebezdina N.S.1, Nekrasova I.V.1
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Affiliations:
- Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- Issue: Vol 160, No 5 (2016)
- Pages: 656-658
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236865
- DOI: https://doi.org/10.1007/s10517-016-3242-4
- ID: 236865
Cite item
Abstract
We studied the ability of melatonin in physiological and pharmacological concentrations to induce and/or regulate differentiation of T cells producing IL-17 (Th17). This hormone produced the opposite effect on CD4+T cells, which depended on their activation status. Melatonin induced the synthesis of IL-17A by intact T cells, but had little effect on activated cells. Melatonin in high (pharmacological) concentration decreased the intracellular expression of this cytokine under conditions of polyclonal activation. Melatonin had a dose-depended effect. Taking into the fact that Th17 cells play an important role in the immune defense, it can be suggested that the regulation of their activity by melatonin contributes to this process.
About the authors
E. M. Kuklina
Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Author for correspondence.
Email: ibis_072@mail.ru
Russian Federation, Perm
N. S. Glebezdina
Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: ibis_072@mail.ru
Russian Federation, Perm
I. V. Nekrasova
Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: ibis_072@mail.ru
Russian Federation, Perm