Variability of the Phenotype and Proliferation and Migration Characteristics of Human Mesenchymal Stromal Cells Derived from the Deciduous Teeth Pulp of Different Donors
- Authors: Vakhrushev I.V.1, Vdovin A.S.1, Strukova L.A.2, Yarygin K.N.1
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Affiliations:
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- Qvadros-Bio Company
- Issue: Vol 160, No 4 (2016)
- Pages: 525-529
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236769
- DOI: https://doi.org/10.1007/s10517-016-3212-x
- ID: 236769
Cite item
Abstract
We performed a comparative study of cell phenotype and proliferation and migration activities in vitro of mesenchymal stromal cells from human exfoliated deciduous teeth (SHED cells) from three donors. In the primary cultures, the cells of different donors had the same morphology and cytophenotype, but differed by proliferative and migration capacities. The results indicate that individual mesenchymal stromal cells cultures can differ considerably by important cell properties, and this should be considered when evaluating their potential therapeutic efficacy and in experimental studies.
About the authors
I. V. Vakhrushev
V. N. Orekhovich Research Institute of Biomedical Chemistry
Author for correspondence.
Email: vakhrunya@gmail.com
Russian Federation, Moscow
A. S. Vdovin
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: vakhrunya@gmail.com
Russian Federation, Moscow
L. A. Strukova
Qvadros-Bio Company
Email: vakhrunya@gmail.com
Russian Federation, Moscow
K. N. Yarygin
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: vakhrunya@gmail.com
Russian Federation, Moscow