Effects of Water-Soluble Polysaccharides with Different Chemical Structure, Isolated from Acorus calamus L. and Trifolium pratense L., on Nitric Oxide Production: A Screening Study
- Authors: Ligacheva A.A.1, Danilets M.G.1, mova E.S.1, Sherstoboev E.Y.1, Zhdanov V.V.1, Guriev A.M.2, Belousov M.V.2, Yusubov M.S.2,3, Korzh A.P.2, Krivoshchekov S.V.2,3, Dygai A.M.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Siberian State Medical University
- National Research Tomsk Polytechnological University
- Issue: Vol 160, No 3 (2016)
- Pages: 330-335
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/236699
- DOI: https://doi.org/10.1007/s10517-016-3163-2
- ID: 236699
Cite item
Abstract
Screening study of the effects of sweet flag (Acorus calamus L.) rhizome and clover (Trifolium pratense L.) aerial part on the production of NO by mouse macrophages was carried out. The polysaccharides were separated by ion exchange chromatography into fractions differing by monomeric composition and ramification type and were used in concentrations of 20, 40, and 100 μg/ml. Four fractions of Acorus calamus L. (PSF-101, PSF-102, PSF-103, and PSF-105), used in different concentrations, moderately stimulated nitrite production by macrophages. Three of five Trifolium pratense L. polysaccharides (PS62-3, PS62-4, and PS62-5) exhibited a significant specific effect on NO production. Rhamnogalactouronans from clover PS63-3 in all concentrations and from PS62-5 in a concentration of 100 μg/ml exhibited the highest activity, comparable to the NO-stimulatory activity of the reference LPS, while polysaccharide PS62-3 in a concentration of 40 μg/ml exhibited even higher activity.
About the authors
A. A. Ligacheva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: m.danilets@mail.ru
Russian Federation, Tomsk
M. G. Danilets
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Author for correspondence.
Email: m.danilets@mail.ru
Russian Federation, Tomsk
E. S. Trofi mova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: m.danilets@mail.ru
Russian Federation, Tomsk
E. Yu. Sherstoboev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: m.danilets@mail.ru
Russian Federation, Tomsk
V. V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: m.danilets@mail.ru
Russian Federation, Tomsk
A. M. Guriev
Siberian State Medical University
Email: m.danilets@mail.ru
Russian Federation, Tomsk
M. V. Belousov
Siberian State Medical University
Email: m.danilets@mail.ru
Russian Federation, Tomsk
M. S. Yusubov
Siberian State Medical University; National Research Tomsk Polytechnological University
Email: m.danilets@mail.ru
Russian Federation, Tomsk; Tomsk
A. P. Korzh
Siberian State Medical University
Email: m.danilets@mail.ru
Russian Federation, Tomsk
S. V. Krivoshchekov
Siberian State Medical University; National Research Tomsk Polytechnological University
Email: m.danilets@mail.ru
Russian Federation, Tomsk; Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: m.danilets@mail.ru
Russian Federation, Tomsk