Remodeling of the Extracellular Matrix of the Liver in Mice with BCG-Induced Granulomatosis after Administration of Liposome-Encapsulated Composition of Oxidized Dextran and Isonicotinic Acid Hydrazide
- Authors: Kim L.B.1, Putyatina A.N.1, Russkikh G.S.1, Shkurupy V.A.1,2
-
Affiliations:
- Federal Research Center of Fundamental and Translational Medicine
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 168, No 2 (2019)
- Pages: 254-258
- Section: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/242389
- DOI: https://doi.org/10.1007/s10517-019-04686-8
- ID: 242389
Cite item
Abstract
Remodeling of the extracellular matrix of the liver in mice with BCG-induced granulomatosis after 2-month course of intraperitoneal injections of isonicotinic acid hydrazide, oxidized dextran conjugated with isonicotinic acid hydrazide, dextrazide, and its liposome-encapsulated form manifested in modification of the proteoglycan composition and hydroxyproline fractions associated with changes in hyaluronidase and MMP activities. The antifibrotic effect of dextrazide and its liposome-encapsulated form manifested in reduction of hydroxyproline fractions that reflected the process of collagen synthesis. Administration of isonicotinic acid hydrazide was followed by a decrease in hydroxyproline fractions reflecting collagen synthesis (antifibrotics effect) and degradation (profibrotic effect), which can be explained by its hepatotoxic activity.
About the authors
L. B. Kim
Federal Research Center of Fundamental and Translational Medicine
Author for correspondence.
Email: lenkim@centercem.ru
Russian Federation, Novosibirsk
A. N. Putyatina
Federal Research Center of Fundamental and Translational Medicine
Email: lenkim@centercem.ru
Russian Federation, Novosibirsk
G. S. Russkikh
Federal Research Center of Fundamental and Translational Medicine
Email: lenkim@centercem.ru
Russian Federation, Novosibirsk
V. A. Shkurupy
Federal Research Center of Fundamental and Translational Medicine; Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: lenkim@centercem.ru
Russian Federation, Novosibirsk; Novosibirsk