Afobazole Alleviates Cognitive Rigidity in Experimental Model of Autism Spectrum Disorders

I. G. Kapitsa; A. P. Kalinina; A. A. Alymov; T. A. Voronina; S. B. Seredenin

doi:10.1007/s10517-019-04682-y

Afobazole Alleviates Cognitive Rigidity in Experimental Model of Autism Spectrum Disorders

Authors: Kapitsa I.G.¹, Kalinina A.P.¹, Alymov A.A.¹, Voronina T.A.¹, Seredenin S.B.¹
Affiliations:
1. V. V. Zakusov Research Institute of Pharmacology
Issue: Vol 168, No 2 (2019)
Pages: 238-241
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/242380
DOI: https://doi.org/10.1007/s10517-019-04682-y
ID: 242380

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Abstract

Afobazole (10 mg/kg) alleviated cognitive rigidity in BALB/c mice, a phenotypic model of autism spectrum disorders. It improved spatial memory and retraining in T-maze with drinking reinforcement and restored the retrieval of acquired skill during reversal learning in Morris water maze.