Email this article Effects of Bariatric Surgeries on the Size of Myocardial Infarction and Ghrelin Level in Rats with Experimental Decompensated Type 2 Diabetes Mellitus
- Authors: Kornyushin O.V.1, Sonin D.L.1, Toropova Y.G.1, Pochkaeva E.I.1, Semikova G.V.2, Berko O.M.2, Zelinskaya I.A.1, Todosenko N.M.3, Litvinova L.S.3, Neimark A.E.4, Babenko A.Y.4, Dergach K.V.5, Schpakov A.O.5, Galagudza M.M.1,2
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Affiliations:
- Institute of Experimental Medicine
- I. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation
- Laboratory of Immunology and Cell Biotechnology, Immanuel Kant Baltic Federal University
- Institute of Endocrinology, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
- Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences
- Issue: Vol 168, No 2 (2019)
- Pages: 210-213
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242365
- DOI: https://doi.org/10.1007/s10517-019-04676-w
- ID: 242365
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Abstract
The effects of bariatric surgeries (sleeve gastrectomy and ileal transposition) on the dynamics of changes in ghrelin level were studied in rats with severe decompensated type 2 diabetes mellitus under conditions of glucose challenge as well as on the size of myocardial infarction in these animals. Diabetes was modelled by high fat diet and a single administration of streptozotocin (25 mg/kg, intraperitoneally). Both bariatric surgeries significantly decreased glucose-induced ghrelin level in the blood of rats with type 2 diabetes mellitus, which attested to an increase in the tissue sensitivity to ghrelin. Sleeve gastrectomy resulted in a decrease in the size of myocardial infarction in diabetic rats, which was calculated as the ratio of the necrosis zone to the zone of the risk of myocardial infarction. Ileal transposition had no effect on this parameter. Our data can be used as the basis for optimization of treatment approaches when using bariatric surgery in the treatment of patients with severe forms of type 2 diabetes mellitus with a high risk of cardiovascular diseases.
About the authors
O. V. Kornyushin
Institute of Experimental Medicine
Author for correspondence.
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
D. L. Sonin
Institute of Experimental Medicine
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
Ya. G. Toropova
Institute of Experimental Medicine
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
E. I. Pochkaeva
Institute of Experimental Medicine
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
G. V. Semikova
I. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
O. M. Berko
I. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
I. A. Zelinskaya
Institute of Experimental Medicine
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
N. M. Todosenko
Laboratory of Immunology and Cell Biotechnology, Immanuel Kant Baltic Federal University
Email: o.kornyushin@gmail.com
Russian Federation, Kaliningrad
L. S. Litvinova
Laboratory of Immunology and Cell Biotechnology, Immanuel Kant Baltic Federal University
Email: o.kornyushin@gmail.com
Russian Federation, Kaliningrad
A. E. Neimark
Institute of Endocrinology, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
A. Yu. Babenko
Institute of Endocrinology, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
K. V. Dergach
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
A. O. Schpakov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg
M. M. Galagudza
Institute of Experimental Medicine; I. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation
Email: o.kornyushin@gmail.com
Russian Federation, St. Petersburg; St. Petersburg
