Effects of Temperature on the Ability of Metabolites from Permafrost Microorganisms to Activate the Synthesis of Systemic Cytokines by Mononuclear Cells
- 作者: Kalenova L.1,2, Kolyvanova S.1,2
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隶属关系:
- Tyumen State University
- Federal Research Centre Tyumen Scientific Centre, Siberian Division of the Russian Academy of Sciences
- 期: 卷 168, 编号 1 (2019)
- 页面: 72-75
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242226
- DOI: https://doi.org/10.1007/s10517-019-04650-6
- ID: 242226
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详细
The effects of metabolites of Bacillus sp. strain M3 and Bacillus megaterium strain 8/75-1 isolated from permafrost formations, as well as a medicinal Bacillus cereus strain IP5832 on the secretion of TNFα, IL-1β, and IL-10 by mononuclear cells of human peripheral blood depending on the temperature of bacteria culturing (-16oC, -5oC, and 42oC) were studied. Metabolites of 8/75-1 and M3 strains cultured at 42oC produced more potent stimulating effect on TNFα and IL-10 synthesis than metabolites from these bacteria cultured at -16oC and -5oC (p<0.01). Temperature did not affect the ability of metabolites to modulate IL-1β synthesis in all bacterial strains and the ability of IP5832 strain metabolites to modulate TNFα production. IL-10 secretion was minimum under the effect of metabolites of IP5832 strain cultured at 42oC. The TNFα/IL-10 and IL-1β/IL-10 ratios indicated that metabolites of permafrost bacteria cultured at 42oC can shift the balance towards the synthesis of proinflammatory cytokines.
作者简介
L. Kalenova
Tyumen State University; Federal Research Centre Tyumen Scientific Centre, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: lkalenova@mail.ru
俄罗斯联邦, Tyumen; Tyumen
S. Kolyvanova
Tyumen State University; Federal Research Centre Tyumen Scientific Centre, Siberian Division of the Russian Academy of Sciences
Email: lkalenova@mail.ru
俄罗斯联邦, Tyumen; Tyumen