Email this article Cortical Somatosensory Neurons in WAG/Rij Rats Transform Firing Evoked by Simulation of Posterior Thalamic Nucleus from Tonic to Phasic at Age of 6 Months
- Authors: Tsvetaeva D.A.1, Sitnikova E.Y.1, Raevsky V.V.1
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Affiliations:
- Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
- Issue: Vol 168, No 1 (2019)
- Pages: 1-4
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/242161
- DOI: https://doi.org/10.1007/s10517-019-04632-8
- ID: 242161
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Abstract
Functional peculiarities of paralemniscal subdivision of the thalamocortical system were examined in normal Wistar and in WAG/Rij rats genetically prone to absence epilepsy. In 6-7-month-old WAG/Rij characterized by developed epileptic activity, the response of cortical somatosensory neurons to single electrical stimulation of the posterior thalamic nucleus was phasic, whereas in normal Wistar rats, similar reaction was tonic. The study views this phasic response as neural equivalent of spike-wave discharges known as typical EEG symptom of absence epilepsy.
About the authors
D. A. Tsvetaeva
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Email: vraevsky@mail.ru
Russian Federation, Moscow
E. Yu. Sitnikova
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Email: vraevsky@mail.ru
Russian Federation, Moscow
V. V. Raevsky
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Author for correspondence.
Email: vraevsky@mail.ru
Russian Federation, Moscow
