Histotopography of α-Gustdusin- and T2R3-Expressing Lymphocytes in Mouse Spleen
- Authors: Cherenkov I.A.1, Sergeyev V.G.1, Nikityuk D.B.2, Chychkov V.M.1
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Affiliations:
- Udmurt State University
- Federal Research Center of Nutrition, Biotechnology, and Food Safety
- Issue: Vol 167, No 6 (2019)
- Pages: 801-804
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242127
- DOI: https://doi.org/10.1007/s10517-019-04626-6
- ID: 242127
Cite item
Abstract
Histotopography of lymphocytes expressing bitter taste receptors of T2R family and α-gustducin (receptor-associated subunit of the G-protein complex) in mouse spleen in the norm and in 48 h after intraperitoneal administration of LPS was studied by the immunohistochemical method. Two populations of immunopositive lymphocytes expressing the above proteins were detected in the spleen; they were located in the marginal zones of lymphoid follicles and periarteriolar lymphoid sheaths. In most α-gustducin-positive lymphocytes, co-expression of α-gustducin and CD19 (B-cell marker) was found. Intraperitoneal administration of LPS significantly increased the number of gustducinergic lymphocytes in periarteriolar lymphoid sheaths. We hypothesize that spleen lymphocytes with gustducin signaling are involved in T-dependent immune response to the blood bacterial polysaccharides.
About the authors
I. A. Cherenkov
Udmurt State University
Email: cellbio@ya.ru
Russian Federation, Izhevsk
V. G. Sergeyev
Udmurt State University
Author for correspondence.
Email: cellbio@ya.ru
Russian Federation, Izhevsk
D. B. Nikityuk
Federal Research Center of Nutrition, Biotechnology, and Food Safety
Email: cellbio@ya.ru
Russian Federation, Moscow
V. M. Chychkov
Udmurt State University
Email: cellbio@ya.ru
Russian Federation, Izhevsk