Myocardial Expression of SERCA2a and Structural and Functional Indices in Patients with Atrial Fibrillation
- Authors: Kondrat’eva D.S.1, Afanas’ev S.A.1, Archakov E.A.1, Tsapko L.P.1, Batalov R.E.1
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Affiliations:
- Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Issue: Vol 167, No 6 (2019)
- Pages: 787-790
- Section: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/242118
- DOI: https://doi.org/10.1007/s10517-019-04623-9
- ID: 242118
Cite item
Abstract
The study examined the relationships between SERCA2a expression in the myocardium and structural and functional indices in patients with atrial fibrillation. In uniform cohort of patients, this expression differed significantly but positively correlated with the size of the left atrium, end-systolic volume, and end-diastolic volume. In contrast, SERCA2a expression negatively correlated with early (peak E) and late (peak A) diastolic filling rates in left ventricle. SERCA2a expression was also associated with echocardiographic parameters reflecting structural and functional status of the heart in patients with persistent atrial fibrillation.
About the authors
D. S. Kondrat’eva
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Author for correspondence.
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk
S. A. Afanas’ev
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk
E. A. Archakov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk
L. P. Tsapko
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk
R. E. Batalov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk