Email this article Cytological Characteristics of a Heterogeneous Population of Hepatocellular Carcinoma-29 Cells after Injection of Lithium Carbonate in the Experiment
- Authors: Taskaeva Y.S.1,2, Bgatova N.P.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Issue: Vol 167, No 6 (2019)
- Pages: 779-783
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242109
- DOI: https://doi.org/10.1007/s10517-019-04621-x
- ID: 242109
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Abstract
Five cytological types of hepatocellular carcinoma-29 (G-29) grown in the muscle tissue of the thigh of experimental animals were identified by transmission electron microscopy; 89% of these were poorly differentiated type I-III cells. Lithium in a concentration of 20 mM produced a damaging effect on poorly differentiated G-29 cells: the number of cells with zones of intracellular component destruction and volume density of these zones increased, while volume density of cisterns of endoplasmic reticulum decreased. These results suggest that lithium carbonate can cause destructive changes in the heterogeneous population of G-29 cells during in vivo tumor development.
About the authors
Yu. S. Taskaeva
Research Institute of Clinical and Experimental Lymphology, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Author for correspondence.
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
N. P. Bgatova
Research Institute of Clinical and Experimental Lymphology, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk
