Effect of Apoptotic Neutrophils on the Production of Erythropoietin, MMP-9, and TIMP-1 in Cultures of Human Macrophages
- Authors: Sakhno L.V.1, Shevela E.Y.1, Lykov A.P.2, Poveshchenko O.V.2, Ostanin A.A.1, Chernykh E.R.1
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Affiliations:
- Research Institute of Fundamental and Clinical Immunology
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
- Issue: Vol 167, No 6 (2019)
- Pages: 755-758
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242092
- DOI: https://doi.org/10.1007/s10517-019-04616-8
- ID: 242092
Cite item
Abstract
We studied the effect of apoptotic neutrophils on the production of erythropoietin, MMP-9, and TIMP-1 by GM-CSF-induced human macrophages. GM-CSF-induced macrophages spontaneously produce erythropoietin and secrete MMP-9 and TIMP-1. Polarization of these macrophages towards the M2-like phenotype after exposure to apoptotic neutrophils considerably increased the production of erythropoietin; the MMP-9/TIMP-1 ratio tended to increase under these conditions due to a decrease in TIMP-1.
About the authors
L. V. Sakhno
Research Institute of Fundamental and Clinical Immunology
Author for correspondence.
Email: lsahno53@mail.ru
Russian Federation, Novosibirsk
E. Ya. Shevela
Research Institute of Fundamental and Clinical Immunology
Email: lsahno53@mail.ru
Russian Federation, Novosibirsk
A. P. Lykov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
Email: lsahno53@mail.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
Email: lsahno53@mail.ru
Russian Federation, Novosibirsk
A. A. Ostanin
Research Institute of Fundamental and Clinical Immunology
Email: lsahno53@mail.ru
Russian Federation, Novosibirsk
E. R. Chernykh
Research Institute of Fundamental and Clinical Immunology
Email: lsahno53@mail.ru
Russian Federation, Novosibirsk