Effect of Apoptotic Neutrophils on the Production of Erythropoietin, MMP-9, and TIMP-1 in Cultures of Human Macrophages

L. V. Sakhno; E. Ya. Shevela; A. P. Lykov; O. V. Poveshchenko; A. A. Ostanin; E. R. Chernykh

doi:10.1007/s10517-019-04616-8

Effect of Apoptotic Neutrophils on the Production of Erythropoietin, MMP-9, and TIMP-1 in Cultures of Human Macrophages

Authors: Sakhno L.V.¹, Shevela E.Y.¹, Lykov A.P.², Poveshchenko O.V.², Ostanin A.A.¹, Chernykh E.R.¹
Affiliations:
1. Research Institute of Fundamental and Clinical Immunology
2. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
Issue: Vol 167, No 6 (2019)
Pages: 755-758
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/242092
DOI: https://doi.org/10.1007/s10517-019-04616-8
ID: 242092

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Abstract

We studied the effect of apoptotic neutrophils on the production of erythropoietin, MMP-9, and TIMP-1 by GM-CSF-induced human macrophages. GM-CSF-induced macrophages spontaneously produce erythropoietin and secrete MMP-9 and TIMP-1. Polarization of these macrophages towards the M2-like phenotype after exposure to apoptotic neutrophils considerably increased the production of erythropoietin; the MMP-9/TIMP-1 ratio tended to increase under these conditions due to a decrease in TIMP-1.

About the authors

L. V. Sakhno

Research Institute of Fundamental and Clinical Immunology

Author for correspondence.
Email: lsahno53@mail.ru
Russian Federation, Novosibirsk