Effect of Tripeptide Leu-Ile-Lys on the Course of Experimental Nephrolithiasis
- Authors: Zharikov A.Y.1, Yakushev N.N.1, Zharikova G.V.1, Mazko O.N.1, Makarova O.G.1, Lepilov A.V.1, Bobrov I.P.1
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Affiliations:
- Altai State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 167, No 6 (2019)
- Pages: 747-750
- Section: New Drugs
- URL: https://journals.rcsi.science/0007-4888/article/view/242085
- DOI: https://doi.org/10.1007/s10517-019-04614-w
- ID: 242085
Cite item
Abstract
We studied the effect of Leu-Ile-Lys tripeptide on the course of experimental oxalate nephrolithiasis modeled in rats by administration of 1% ethylene glycol solution instead of drinking water for 6 weeks. The Leu-Ile-Lys tripeptide obtained by chemical synthesis (purity ≥98%) was administered through a gastric tube (11.5 mg/kg in 1 ml saline). Administration of Leu-Ile-Lys tripeptide against the background of experimental oxalate nephrolithiasis significantly alleviated the course of experimental pathology, which was confirmed by typical biochemical and morphological changes: decrease in urinary activity of γ-glutamyltransferase (by 2.1 times in comparison with the initial level) and intensity of oxidative stress (the content of TBA-reactive products decreased by 1.3 times in comparison with that in untreated animals) and increase in glutathione peroxidase activity by 1.8 times; no histological signs of nephrolithiasis were found in animals treated with the tripeptide.
About the authors
A. Yu. Zharikov
Altai State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: zharikov_a_y@mail.ru
Russian Federation, Barnaul
N. N. Yakushev
Altai State Medical University, Ministry of Health of the Russian Federation
Email: zharikov_a_y@mail.ru
Russian Federation, Barnaul
G. V. Zharikova
Altai State Medical University, Ministry of Health of the Russian Federation
Email: zharikov_a_y@mail.ru
Russian Federation, Barnaul
O. N. Mazko
Altai State Medical University, Ministry of Health of the Russian Federation
Email: zharikov_a_y@mail.ru
Russian Federation, Barnaul
O. G. Makarova
Altai State Medical University, Ministry of Health of the Russian Federation
Email: zharikov_a_y@mail.ru
Russian Federation, Barnaul
A. V. Lepilov
Altai State Medical University, Ministry of Health of the Russian Federation
Email: zharikov_a_y@mail.ru
Russian Federation, Barnaul
I. P. Bobrov
Altai State Medical University, Ministry of Health of the Russian Federation
Email: zharikov_a_y@mail.ru
Russian Federation, Barnaul