Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine
- Authors: Poletaeva D.A.1, Faingold I.I.1,2, Soldatova Y.V.1,2, Smolina A.V.1, Fedorov B.S.1, Eremeev A.B.1, Kotelnikova R.A.1
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Scientific Educational Center, Moscow Regional State University
- Issue: Vol 167, No 6 (2019)
- Pages: 744-746
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242082
- DOI: https://doi.org/10.1007/s10517-019-04613-x
- ID: 242082
Cite item
Abstract
We studied membranotropic properties of NO donor 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and its structural analog succinate 3-hydroxy-6-methyl-2-ethylpyridine (Mexidol). It was shown that the compounds under study are incorporated into modeled membranes and form long-living complexes with pyrene in the region of fatty acid tails of phospholipids. Luminol-amplified chemiluminescence analysis showed that both compounds exhibited antiradical activity and in a concentration of 0.1 mM reduced chemiluminescence intensity by more than 70%. 2-Nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine inhibited catalytic activity of monoamine oxidase A more efficiently than its structural analogue Mexidol.
About the authors
D. A. Poletaeva
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: daryazhokhkova@gmail.com
Russian Federation, Chernogolovka
I. I. Faingold
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Scientific Educational Center, Moscow Regional State University
Email: daryazhokhkova@gmail.com
Russian Federation, Chernogolovka; Chernogolovka
Yu. V. Soldatova
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Scientific Educational Center, Moscow Regional State University
Email: daryazhokhkova@gmail.com
Russian Federation, Chernogolovka; Chernogolovka
A. V. Smolina
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: daryazhokhkova@gmail.com
Russian Federation, Chernogolovka
B. S. Fedorov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: daryazhokhkova@gmail.com
Russian Federation, Chernogolovka
A. B. Eremeev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: daryazhokhkova@gmail.com
Russian Federation, Chernogolovka
R. A. Kotelnikova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: daryazhokhkova@gmail.com
Russian Federation, Chernogolovka