Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range
- Авторлар: Vasilieva N.A.1, Shevtsova E.F.1, Van’kin G.I.1, Lermontova N.N.1, Serkova T.P.1, Nikolaeva N.S.1, Bachurin S.O.1
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Мекемелер:
- Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
- Шығарылым: Том 167, № 6 (2019)
- Беттер: 740-743
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/242077
- DOI: https://doi.org/10.1007/s10517-019-04612-y
- ID: 242077
Дәйексөз келтіру
Аннотация
Comparison of the cognition-stimulating effects of Dimebon in a wide dose range revealed a non-monotonic and nontrivial wave-like dose-dependence of its activity. Positive results were obtained at low (0.02-0.05 mg/kg) or high (5-10 mg/kg) doses of Dimebon, while intermediate doses were ineffective. This type of the dose dependence of the pharmacological effect can indicate that the substance has several targets. This fact should be taken into consideration when selecting the doses and concentrations of the substance and its analogues for further studies, and for planning treatment schemes and administration doses in clinical studies.
Авторлар туралы
N. Vasilieva
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Ресей, Chernogolovka, Moscow region
E. Shevtsova
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: e.f.shevtsova@gmail.com
Ресей, Chernogolovka, Moscow region
G. Van’kin
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Ресей, Chernogolovka, Moscow region
N. Lermontova
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Ресей, Chernogolovka, Moscow region
T. Serkova
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Ресей, Chernogolovka, Moscow region
N. Nikolaeva
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Ресей, Chernogolovka, Moscow region
S. Bachurin
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Ресей, Chernogolovka, Moscow region
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