Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range
- Authors: Vasilieva N.A.1, Shevtsova E.F.1, Van’kin G.I.1, Lermontova N.N.1, Serkova T.P.1, Nikolaeva N.S.1, Bachurin S.O.1
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Affiliations:
- Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
- Issue: Vol 167, No 6 (2019)
- Pages: 740-743
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/242077
- DOI: https://doi.org/10.1007/s10517-019-04612-y
- ID: 242077
Cite item
Abstract
Comparison of the cognition-stimulating effects of Dimebon in a wide dose range revealed a non-monotonic and nontrivial wave-like dose-dependence of its activity. Positive results were obtained at low (0.02-0.05 mg/kg) or high (5-10 mg/kg) doses of Dimebon, while intermediate doses were ineffective. This type of the dose dependence of the pharmacological effect can indicate that the substance has several targets. This fact should be taken into consideration when selecting the doses and concentrations of the substance and its analogues for further studies, and for planning treatment schemes and administration doses in clinical studies.
About the authors
N. A. Vasilieva
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Russian Federation, Chernogolovka, Moscow region
E. F. Shevtsova
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Author for correspondence.
Email: e.f.shevtsova@gmail.com
Russian Federation, Chernogolovka, Moscow region
G. I. Van’kin
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Russian Federation, Chernogolovka, Moscow region
N. N. Lermontova
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Russian Federation, Chernogolovka, Moscow region
T. P. Serkova
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Russian Federation, Chernogolovka, Moscow region
N. S. Nikolaeva
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Russian Federation, Chernogolovka, Moscow region
S. O. Bachurin
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: e.f.shevtsova@gmail.com
Russian Federation, Chernogolovka, Moscow region