Evaluation of Allergenic, Immunogenic, and Skin-Irritant Effects of Deicing Chemicals in Warm-Blooded Animals
- Authors: Vodyanova M.A.1, Kryatov I.A.1, Chudakova S.B.1, Ushakova O.V.1, Evseeva I.S.1, Makovetskaya A.K.1, Mislavsky O.V.1
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Affiliations:
- Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
- Issue: Vol 167, No 5 (2019)
- Pages: 656-659
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241993
- DOI: https://doi.org/10.1007/s10517-019-04592-z
- ID: 241993
Cite item
Abstract
We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity and in high doses can cause delayed-type hypersensitivity reaction that manifested in skin irritant effect on the skin and produced a suppressive effect on the humoral immunity. The modified method for assessing skin irritation proposed by us is more sensitive than standard methods.
About the authors
M. A. Vodyanova
Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
Author for correspondence.
Email: lab.pochva@mail.ru
Russian Federation, Moscow
I. A. Kryatov
Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
Email: lab.pochva@mail.ru
Russian Federation, Moscow
S. B. Chudakova
Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
Email: lab.pochva@mail.ru
Russian Federation, Moscow
O. V. Ushakova
Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
Email: lab.pochva@mail.ru
Russian Federation, Moscow
I. S. Evseeva
Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
Email: lab.pochva@mail.ru
Russian Federation, Moscow
A. K. Makovetskaya
Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
Email: lab.pochva@mail.ru
Russian Federation, Moscow
O. V. Mislavsky
Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation
Email: lab.pochva@mail.ru
Russian Federation, Moscow