Combined Action of GDNF and HGF Up-Regulates Axonal Growth by Increasing ERK1/2 Phosphorylation
- Authors: Molokotina Y.D.1, Boldyreva М.А.1,2, Stafeev I.S.1,2, Semina E.V.1,2, Shevchenko E.K.1,2, Zubkova E.S.1,2, Beloglazova I.B.1,2, Parfenova E.V.1,2
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Affiliations:
- National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
- Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
- Issue: Vol 167, No 3 (2019)
- Pages: 413-417
- Section: Methods
- URL: https://journals.rcsi.science/0007-4888/article/view/241770
- DOI: https://doi.org/10.1007/s10517-019-04539-4
- ID: 241770
Cite item
Abstract
A stimulating effect of a combination of hepatocyte growth factor (HGF) and glial neurotrophic factor (GDNF) on the growth of neurites in the spinal ganglion model was demonstrated. The mechanism of neurite growth in the spinal ganglion model is associated with transactivation of HGF c-met receptor in the presence of both HGF and GDNF. The combination of HGF and GDNF significantly activated mitogenic signaling cascade mediated by protein kinases ERK1/2, which can be a mechanism for increasing the number of neurites. Our findings can be used for developing effective methods for restoring impaired peripheral nerve function after traumatic and ischemic injury using a combination of GDNF and HGF.
About the authors
Yu. D. Molokotina
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: mboldyreva@inbox.ru
Russian Federation, Moscow
М. А. Boldyreva
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: mboldyreva@inbox.ru
Russian Federation, Moscow; Moscow
I. S. Stafeev
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: mboldyreva@inbox.ru
Russian Federation, Moscow; Moscow
E. V. Semina
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: mboldyreva@inbox.ru
Russian Federation, Moscow; Moscow
E. K. Shevchenko
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: mboldyreva@inbox.ru
Russian Federation, Moscow; Moscow
E. S. Zubkova
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: mboldyreva@inbox.ru
Russian Federation, Moscow; Moscow
I. B. Beloglazova
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: mboldyreva@inbox.ru
Russian Federation, Moscow; Moscow
E. V. Parfenova
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: mboldyreva@inbox.ru
Russian Federation, Moscow; Moscow