Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress
- Authors: Fomenko E.V.1, Bobyntsev I.I.2,3, Ivanov A.V.1,3, Belykh A.E.2,3, Andreeva L.A.4, Myasoedov N.F.4
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Affiliations:
- Department of Histology, Cytology, and Embryology
- Department of Pathophysiology
- Research Institute of General Pathology, Kursk State Medical University
- Department of Chemistry of Physiologically Active Substances, Institute of Molecular Genetics, Russian Academy of Sciences
- Issue: Vol 167, No 2 (2019)
- Pages: 293-296
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241657
- DOI: https://doi.org/10.1007/s10517-019-04512-1
- ID: 241657
Cite item
Abstract
We studied the effects of Selank on morphological parameters of the liver in Wistar male rats subjected to chronic foot-shock stress. Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session. Morphological and morphometrical analysis showed that chronic foot-shock stress induced hydropic degeneration of hepatocytes, an increase of the nucleus/cytoplasm ratio due to an increase in the area of nuclei and reduction of the cytoplasm area, the appearance of focal necroses, and lymphohistiocyte infiltration. Injection of Selank in all doses reduced the intensity of stress-induced degenerative changes. Administration of Selank in doses of 300 and 1000 μg/kg restored the nucleus/cytoplasm ratio in hepatocytes. The maximum stress-limiting effect was attained after administration of 300 μg/kg Selank.
About the authors
E. V. Fomenko
Department of Histology, Cytology, and Embryology
Email: bobig@mail.ru
Russian Federation, Moscow
I. I. Bobyntsev
Department of Pathophysiology; Research Institute of General Pathology, Kursk State Medical University
Author for correspondence.
Email: bobig@mail.ru
Russian Federation, Moscow; Kursk
A. V. Ivanov
Department of Histology, Cytology, and Embryology; Research Institute of General Pathology, Kursk State Medical University
Email: bobig@mail.ru
Russian Federation, Moscow; Kursk
A. E. Belykh
Department of Pathophysiology; Research Institute of General Pathology, Kursk State Medical University
Email: bobig@mail.ru
Russian Federation, Moscow; Kursk
L. A. Andreeva
Department of Chemistry of Physiologically Active Substances, Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Russian Federation, Moscow
N. F. Myasoedov
Department of Chemistry of Physiologically Active Substances, Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Russian Federation, Moscow