Email this article N-Terminal Fragment of Brain-Type Natriuretic Peptide (NT-proBNP) as a Prognostic Marker in Patients with Newly Diagnosed Multiple Myeloma Complicated by Dialysis-Dependent Renal Failure
- Authors: Semochkin S.V.1,2, Misyurina E.N.1, Zhelnova E.I.1, Yurova E.V.2, Gagloeva D.E.1, Aref’eva N.A.1, Ushakova A.I.1, Kotenko O.N.1, Tolstykh T.N.1, Sinyavkin D.O.1, Baryakh E.A.1,2, Yatskov K.V.1, Samsonova I.V.1, Lysenko M.A.1
-
Affiliations:
- Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 167, No 2 (2019)
- Pages: 267-271
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/241636
- DOI: https://doi.org/10.1007/s10517-019-04506-z
- ID: 241636
Cite item
Open Access
Access granted
Subscription Access
Abstract
Prognostic value of N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP) was analyzed in patients with multiple myeloma complicated by dialysisdependent renal failure. The prospective study included 20 patients with newly diagnosed multiple myeloma. The concentrations of NT-proBNP were measured before antimyeloma chemotherapy. The median age of the patients was 67 (63-76) years. The median glomerular filtration rate was 4 (4, 5) ml/min/1.73 m2. For overall survival, the area under ROC curve was 0.75 and the cut-off point was 7000 pg/ml. At median follow-up of 17.3 months, the overall survival was 76.6±14.8 and 27.3±13.4% (p=0.02) for cases with NT-proBNP levels below and above the cut-off point, respectively. There were no cases of death due to cardiovascular causes. We concluded that the increase in serum concentration of NT-proBNP>7400 pg/ml is associated with the severity of kidney damage and the risk of non-cardiac mortality.
About the authors
S. V. Semochkin
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow; Moscow
E. N. Misyurina
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
E. I. Zhelnova
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
E. V. Yurova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
D. E. Gagloeva
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
N. A. Aref’eva
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
A. I. Ushakova
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
O. N. Kotenko
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
T. N. Tolstykh
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
D. O. Sinyavkin
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
E. A. Baryakh
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow; Moscow
K. V. Yatskov
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
I. V. Samsonova
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
M. A. Lysenko
Municipal Clinical Hospital No. 52, Moscow Healthcare Department, Ministry of Health of the Russian Federation
Email: semochkin_sv@rsmu.ru
Russian Federation, Moscow
