Relaxation Properties of Contrast Media for MRI Based on Iron Oxide Nanoparticles in Different Magnetic Fields

V. P. Chekhonin; M. A. Abakumov; A. G. Mazhuga; A. N. Bagdinova; E. I. Demikhov; T. E. Demikhov; B. Ya. Mishkinis; M. V. Konstantinov; V. P. Tarasov; B. A. Shumm; A. A. Gippius; N. V. Gervits; A. B. Shumm

doi:10.1007/s10517-019-04469-1

Relaxation Properties of Contrast Media for MRI Based on Iron Oxide Nanoparticles in Different Magnetic Fields

Authors: Chekhonin V.P.¹, Abakumov M.A.¹, Mazhuga A.G.², Bagdinova A.N.³, Demikhov E.I.³, Demikhov T.E.³, Mishkinis B.Y.⁴, Konstantinov M.V.³, Tarasov V.P.³, Shumm B.A.³, Gippius A.A.³, Gervits N.V.³, Shumm A.B.³
Affiliations:
1. N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
2. D. I. Mendeleev University of Chemical Technology of Russia
3. P. N. Lebedev Physical Institute of the Russian Academy of Sciences
4. S. P. HELPIC
Issue: Vol 167, No 1 (2019)
Pages: 97-99
Section: Biotechnologies
URL: https://journals.rcsi.science/0007-4888/article/view/241487
DOI: https://doi.org/10.1007/s10517-019-04469-1
ID: 241487

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Abstract

We studied dependences of T2 relaxation time on magnetic field and concentration of nanoparticles. It was found that nanocontrast media are effective under the influence of the magnetic fields in the range 0.3-7 T. Data of electron paramagnetic resonance confirm the assumption on aggregation of nanoparticles not coated with proteins in high magnetic fields.