Email this article Ultrastructural Changes in Hepatocellular Carcinoma-29 Cells after Treatment with Lithium Carbonate
- Authors: Taskaeva Y.S.1,2, Bgatova N.P.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Issue: Vol 167, No 1 (2019)
- Pages: 87-90
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241474
- DOI: https://doi.org/10.1007/s10517-019-04467-3
- ID: 241474
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Abstract
We studied the effect of lithium carbonate on hepatocellular carcinoma-29 cells in CBA male mice after injection in a dose of 20 mM along the tumor periphery. Transmission electron microscopy revealed a decrease in the volume density of the granular endoplasmic reticulum in the cell cytoplasm and an increase in the total numerical and volume density of autophagosomes and autolysosomes and zones of destruction of intracellular organelles. The ability of lithium carbonate to activate intracellular degradation processes in tumor cells and to stimulate cell death can be used to develop new combined strategies in the chemotherapy for hepatocellular carcinoma.
About the authors
Yu. S. Taskaeva
Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Author for correspondence.
Email: inabrite@yandex.ru
Russian Federation, Siberia; Novosibirsk
N. P. Bgatova
Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: inabrite@yandex.ru
Russian Federation, Siberia
