Secretome of Cultured Human Endothelial Cells in Simulated Microgravity
- Authors: Kashirina D.N.1, Kononikhin A.S.1, Larina I.M.1, Buravkova L.B.1
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Affiliations:
- State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
- Issue: Vol 167, No 1 (2019)
- Pages: 35-38
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241422
- DOI: https://doi.org/10.1007/s10517-019-04454-8
- ID: 241422
Cite item
Abstract
The secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and in modeled microgravity for 24 h was studied by chromatography-mass spectrometry. In the secretome of cells exposed to microgravity, we identified a group of microtubule proteins including many structural elements of microtubules and regulatory proteins interacting with Rho-GTPases. Hence, reorganization of actin cytoskeleton and microtubules induced by microgravity is under complex regulation mediated by Rho proteins.
About the authors
D. N. Kashirina
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Author for correspondence.
Email: daryakudryavtseva@mail.ru
Russian Federation, Moscow
A. S. Kononikhin
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: daryakudryavtseva@mail.ru
Russian Federation, Moscow
I. M. Larina
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: daryakudryavtseva@mail.ru
Russian Federation, Moscow
L. B. Buravkova
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: daryakudryavtseva@mail.ru
Russian Federation, Moscow