Email this article Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction
- Authors: Spasov A.A.1, Kucheryavenko A.F.1, Sirotenko V.S.1, Anisimova V.A.2, Divaeva L.N.2, Kuz’menko T.A.2, Morkovnik A.S.2
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Affiliations:
- Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Issue: Vol 166, No 6 (2019)
- Pages: 747-750
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241332
- DOI: https://doi.org/10.1007/s10517-019-04432-0
- ID: 241332
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Abstract
Antithrombotic activity of a novel tricyclic derivative of diazepino[1,2-α]benzimidazole (DAB-15) was examined on the model of arterial thrombosis developed in rats without concomitant pathology and in rats with experimental myocardial infarction. DAB-15 demonstrated high antithrombotic efficacy in modeled thrombosis of carotid artery in rats without the concomitant pathology surpassing that of the reference drugs acetylsalicylic acid and clopidogrel by 5.1 and 4.8 times, respectively. In rats with experimental noncoronary myocardial infarction, DAB-15 increased the thrombus formation time by 86.2% in comparison with experimental control level in non-treated rats with similar myocardial infarction.
About the authors
A. A. Spasov
Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Russian Federation, Volgograd
A. F. Kucheryavenko
Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: aidakucheryavenko@yandex.ru
Russian Federation, Volgograd
V. S. Sirotenko
Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Russian Federation, Volgograd
V. A. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Russian Federation, Rostov-on-Don
L. N. Divaeva
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Russian Federation, Rostov-on-Don
T. A. Kuz’menko
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Russian Federation, Rostov-on-Don
A. S. Morkovnik
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Russian Federation, Rostov-on-Don
