Transcriptome Guided Drug Combination Suppresses Proliferation of Breast Cancer Cells
- Authors: Shkurnikov M.Y.1, Poloznikov A.A.1, Nikulin S.V.2, Schumacher U.3, Wicklein D.3, Stürken C.3, Galatenko V.V.2, Alekseev B.Y.1
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Affiliations:
- P. A. Hertsen Moscow Oncology Research Center, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
- BioClinicum Research Center
- University Medical Center Hamburg-Eppendorf
- Issue: Vol 166, No 5 (2019)
- Pages: 656-660
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241258
- DOI: https://doi.org/10.1007/s10517-019-04412-4
- ID: 241258
Cite item
Abstract
One of actively developing trends in modern pharmacology is the use of the transcriptome analysis for drug repositioning. We have previously detected two molecular markers of relapses in patients with malignant breast tumors: ELOVL5 and IGFBP6. Poor prognosis is associated with low expression of these markers. Here we analyze the effects of simvastatin and a new potential proteasome inhibitor K7174 inducing expression of IGFBP6 and EVOVL5 on the proliferation of breast cancer cells MDA-MB-231 and DU4475. Compound K7174 potentiates the inhibitory effect of simvastatin on the proliferation of DU4475 cells characterized by low expression of ELOVL5-IGFBP6 pair, but not on the proliferation of MDA-MB-231 cells with high expression of these markers.
About the authors
M. Yu. Shkurnikov
P. A. Hertsen Moscow Oncology Research Center, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Moscow
A. A. Poloznikov
P. A. Hertsen Moscow Oncology Research Center, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Moscow
S. V. Nikulin
BioClinicum Research Center
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Moscow
U. Schumacher
University Medical Center Hamburg-Eppendorf
Email: andrey.poloznikov@nmicr.ru
Germany, Hamburg
D. Wicklein
University Medical Center Hamburg-Eppendorf
Email: andrey.poloznikov@nmicr.ru
Germany, Hamburg
C. Stürken
University Medical Center Hamburg-Eppendorf
Email: andrey.poloznikov@nmicr.ru
Germany, Hamburg
V. V. Galatenko
BioClinicum Research Center
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Moscow
B. Ya. Alekseev
P. A. Hertsen Moscow Oncology Research Center, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Moscow
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