Reception of Sex Steroid Hormones in Thyroid Papillary Cancer Tissue and Relationship with Expression and Content of Transcription Factors Brn-3α and TRIM16

L. V. Spirina; S. Yu. Chizhevskaya; I. V. Kondakova; E. L. Choinzonov

doi:10.1007/s10517-018-4322-4

Reception of Sex Steroid Hormones in Thyroid Papillary Cancer Tissue and Relationship with Expression and Content of Transcription Factors Brn-3α and TRIM16

Authors: Spirina L.V.¹^,2, Chizhevskaya S.Y.¹, Kondakova I.V.¹, Choinzonov E.L.¹^,2
Affiliations:
1. Russian Academy of Sciences
2. Siberian State Medical University
Issue: Vol 166, No 2 (2018)
Pages: 237-240
Section: Oncology
URL: https://journals.rcsi.science/0007-4888/article/view/240928
DOI: https://doi.org/10.1007/s10517-018-4322-4
ID: 240928

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Abstract

We studied reception of sex steroid hormones in the tissues of thyroid papillary cancer and benign tumor. Enhanced expression of AR and ERβ mRNA reflected malignant tumor growth. Nuclear factors Brn-3α and TRIM16 modulating expression of steroid hormones play an important role in the development of thyroid tumors. It was found that the level of TRIM16 mRNA is associated with the expression of ERβ, which seems to be mediated by its antiestrogen effect.