Induction of Vasculo- and Osteogenesis in Spheroids Formed by Adipose-Derived Stromal Cells
- 作者: Saburina I.N.1,2, Gorkun A.A.1, Fidarov A.F.3, Kolokol’tsova T.D.1,2, Zurina I.M.1, Kosheleva N.V.1,2, Ustinova E.E.1, Repin V.S.1
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隶属关系:
- Research Institute of General Pathology and Pathophysiology
- Biological Faculty, M. V. Lomonosov Moscow State University
- Russian Medical Academy of Postgraduate Education
- 期: 卷 166, 编号 1 (2018)
- 页面: 163-169
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/240886
- DOI: https://doi.org/10.1007/s10517-018-4306-4
- ID: 240886
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详细
Vascularization of bioengineered bone tissue constructs remains a challenging problem of regenerative medicine. Spheroids generated in 3D culture of adipose-derived stromal cells supplemented with inducing factors demonstrate stable characteristics and express of mesenchymal, endothelial, and osteoblasts markers, and represent a prototype of vascularized microtissue. Adipose-derived stromal cells spheroids induced to both angio- and osteogenic differentiation can be used in development of new innovative technologies for in vitro fabrication of vascularized bioequivalents for repair of large bone defects.
作者简介
I. Saburina
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow; Moscow
A. Gorkun
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow
A. Fidarov
Russian Medical Academy of Postgraduate Education
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow
T. Kolokol’tsova
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow; Moscow
I. Zurina
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow
N. Kosheleva
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow; Moscow
E. Ustinova
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow
V. Repin
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow
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