Induction of Vasculo- and Osteogenesis in Spheroids Formed by Adipose-Derived Stromal Cells


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Vascularization of bioengineered bone tissue constructs remains a challenging problem of regenerative medicine. Spheroids generated in 3D culture of adipose-derived stromal cells supplemented with inducing factors demonstrate stable characteristics and express of mesenchymal, endothelial, and osteoblasts markers, and represent a prototype of vascularized microtissue. Adipose-derived stromal cells spheroids induced to both angio- and osteogenic differentiation can be used in development of new innovative technologies for in vitro fabrication of vascularized bioequivalents for repair of large bone defects.

作者简介

I. Saburina

Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University

Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow; Moscow

A. Gorkun

Research Institute of General Pathology and Pathophysiology

Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow

A. Fidarov

Russian Medical Academy of Postgraduate Education

Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow

T. Kolokol’tsova

Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow; Moscow

I. Zurina

Research Institute of General Pathology and Pathophysiology

Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow

N. Kosheleva

Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University

Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow; Moscow

E. Ustinova

Research Institute of General Pathology and Pathophysiology

Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow

V. Repin

Research Institute of General Pathology and Pathophysiology

Email: kolokoltd@mail.ru
俄罗斯联邦, Moscow

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