Aminoethane Sulfonic Acid Magnesium Salt Inhibits Ca2+ Entry Through NMDA Receptor Ion Channel In Vitro
- Authors: Turovsky E.A.1, Blinova E.V.2, Semeleva E.V.2, Zinchenko V.P.1, Astashev M.E.1, Blinov D.S.3, Skachilova S.Y.3, Geras’kina M.M.2, Lebedev A.B.3, Gromova I.A.2
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Affiliations:
- Institute of Cell Biophysics, Russian Academy of Science
- N. P. Ogarev National Research Mordovian State University
- Russian Research Center for Safety of Bioactive Substances
- Issue: Vol 166, No 1 (2018)
- Pages: 39-42
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240815
- DOI: https://doi.org/10.1007/s10517-018-4284-6
- ID: 240815
Cite item
Abstract
The effect of a cerebroprotective agent magnesium bis-aminoethanesulfonate (laboratory code FS-LKhT-317) on intracellular calcium concentration was studied by the fluorescent imaging technique on neuroglial cell culture from Spraque-Dawley rat hippocampus. The substance produced a pronounced inhibitory effect and suppressed NMDA receptor activity in concentrations of ≥50 μM. The observed effects were reversible or partially reversible and were detected by a decrease in Ca2+ signal amplitude in neurons in response to NMDA applications in a Mg2+-free medium and by inhibition of Ca2+ pulses in magnesium-free medium (elimination of magnesium block).
About the authors
E. A. Turovsky
Institute of Cell Biophysics, Russian Academy of Science
Email: bev-saransk@yandex.ru
Russian Federation, Pushchino
E. V. Blinova
N. P. Ogarev National Research Mordovian State University
Author for correspondence.
Email: bev-saransk@yandex.ru
Russian Federation, Saransk
E. V. Semeleva
N. P. Ogarev National Research Mordovian State University
Email: bev-saransk@yandex.ru
Russian Federation, Saransk
V. P. Zinchenko
Institute of Cell Biophysics, Russian Academy of Science
Email: bev-saransk@yandex.ru
Russian Federation, Pushchino
M. E. Astashev
Institute of Cell Biophysics, Russian Academy of Science
Email: bev-saransk@yandex.ru
Russian Federation, Pushchino
D. S. Blinov
Russian Research Center for Safety of Bioactive Substances
Email: bev-saransk@yandex.ru
Russian Federation, Staraya Kupavna
S. Ya. Skachilova
Russian Research Center for Safety of Bioactive Substances
Email: bev-saransk@yandex.ru
Russian Federation, Staraya Kupavna
M. M. Geras’kina
N. P. Ogarev National Research Mordovian State University
Email: bev-saransk@yandex.ru
Russian Federation, Saransk
A. B. Lebedev
Russian Research Center for Safety of Bioactive Substances
Email: bev-saransk@yandex.ru
Russian Federation, Staraya Kupavna
I. A. Gromova
N. P. Ogarev National Research Mordovian State University
Email: bev-saransk@yandex.ru
Russian Federation, Saransk