fMRI Response of Parietal Brain Areas to Sad Facial Stimuli in Mild Depression
- 作者: Mel’nikov M.E.1,2, Petrovskii E.D.3, Bezmaternykh D.D.1,2, Kozlova L.I.1,2, Shtark M.B.1,2, Savelov A.A.3, Shubina O.S.1, Natarova K.A.4
-
隶属关系:
- Research Institute of Molecular Biology and Biophysics
- Novosibirsk National Research State University
- International Tomography Center, Siberian Division of Russian Academy of Sciences
- International Institute of Psychology and Psychotherapy
- 期: 卷 165, 编号 6 (2018)
- 页面: 741-745
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240718
- DOI: https://doi.org/10.1007/s10517-018-4255-y
- ID: 240718
如何引用文章
详细
fMRI markers of mild depression were revealed using standard emotional test. Patients with mild depression and healthy volunteers were asked to determine gender of subjects in photographs with different emotional expressions (neutral, surprise, disgust, confusion, anger, sadness, fear, and joy). The pattern of response to different emotions was universal in both groups and included the largest clusters in the occipital region, as well as a certain volume in the parietal lobes and posterior lateral frontal cortex. In depression group, a lack of activation in the middle cingulate gyrus (bilaterally) and in the postcentral and inferior parietal gyrus (left) in response to presentation of sad faces. For other emotion, no large clusters of intergroup contrasts significant at p<0.05 with FWE correction were revealed. The response of the middle cingulate gyrus and the left inferior parietal lobe can be considered as a potential diagnostic marker of depressive disorders and as the target for neurofeedback.
作者简介
M. Mel’nikov
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
编辑信件的主要联系方式.
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
E. Petrovskii
International Tomography Center, Siberian Division of Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
D. Bezmaternykh
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
L. Kozlova
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
M. Shtark
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
A. Savelov
International Tomography Center, Siberian Division of Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
O. Shubina
Research Institute of Molecular Biology and Biophysics
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
K. Natarova
International Institute of Psychology and Psychotherapy
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
补充文件
